https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Development of frontoparietal connectivity predicts longitudinal symptom changes in young people with autism spectrum disorder https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45018 p < 0.001). There was a significant interaction between diagnosis and time in brain development (p < 0.001). This was expressed by a decrease in structural connectivity within the frontoparietal network—and its broader connectivity—in ASD during adolescence and early adulthood. Conversely, these connections increased with time in TDC. Crucially, stronger baseline connectivity in this subnetwork predicted a lower symptom load at follow-up (p = 0.048), independent of the expression of symptoms at baseline. Our findings suggest a clinically meaningful relationship between the atypical development of frontoparietal structural connections and the dynamics of the autism phenotype through early adulthood. These results highlight a potential marker of future outcome.]]> Wed 26 Oct 2022 10:17:49 AEDT ]]> Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51039 -2, threshold = 2.5 × 10-2). For the GenLang Cohort (n = 26,558), SNPs in DOCK7 and CDH4 showed significant association for the NM/AG hypothesis (sFDR q = 1.02 × 10-2). To make the GenLang dataset more similar to Toronto, we repeated the analysis restricting to samples selected for reading/language deficits (n = 4152). In this GenLang selected subset, we found significant association for a locus intergenic between BTG3-C21orf91 for both hypotheses (sFDR q < 9.00 × 10-4). This study contributes candidate loci to the genetics of word reading. Data also suggest that, although different variants may be involved, alleles implicated in ASD risk may be found in the same genes as those implicated in word reading. This finding is limited to the Toronto sample suggesting that ascertainment influences genetic associations.]]> Wed 16 Aug 2023 10:23:40 AEST ]]> How are attention, learning, and social cognition related on the non-clinical autistic spectrum? https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40162 Wed 06 Jul 2022 10:15:43 AEST ]]> An altered glial phenotype in the NL3R451C mouse model of autism https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49605 Tue 23 May 2023 16:01:03 AEST ]]> Modeling relations among coparenting quality, autism-specific parenting self-efficacy, and parenting stress in mothers and fathers of children with ASD https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28273 Sat 24 Mar 2018 07:28:31 AEDT ]]>